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Anti-BECN1 Rabbit Polyclonal Antibody

Leverancier: Thermo Scientific
Suggested positive control: antigen standard for BECN1 (transient overexpression lysate). Beclin 1 is the first identified mammalian gene to mediate autophagy and also has tumor suppressor and antiviral function. Autophagy, a process of bulk protein degradation through an autophagosomic-lysosomal pathway, is important for differentiation, survival during nutrient deprivation, and normal growth control, and is often defective in tumor cells. Beclin 1 was originally isolated in a yeast two hybrid screen to identify Bcl-2-binding partners and maps to a tumor susceptibility locus on human chromosome 17q21 that is frequently monoallelically deleted in human breast, ovarian and prostate cancer. Beclin 1 encodes an evolutionarily conserved 60 kDa coiled coil protein that is expressed in human muscle, epithelial cells and neurons. In gene transfer studies, beclin 1 promotes nutrient deprivation-induced autophagy, inhibits mammary tumorigenesis, and inhibits viral replication. Expression of the Beclin 1 protein is frequently decreased in malignant breast epithelial cells. Based upon these observations, it is speculated that beclin 1 may work through induction of autophagy to negatively regulate tumorigenesis and to control viral infections. Beclin 1 may also play a role in other biologic processes in which autophagy is important such as cell differentiation and nutritional stress responses.

Type: Primary
Antigen: BECN1
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse




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Maat VPE VWR catalogus nummer Hoeveelheid
100 µL 100 µl PIEAPA116939 Blocked
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Specificaties

Antigen symbol BECN1
Antigen name Beclin 1
Reactivity Mouse, Human
Conjugation Unconjugated
Clonality Polyclonal
Antibody type Primary
Host Rabbit
Isotype IgG
Western blot Yes
ImmunoFluorescence Yes
Antigen synonyms CTIP-1 COUP-TF interacting protein 1 antibody, Beclin1 autophagy antibody.
Gene ID 56208, 8678
Formaat whole serum
Immunogen Full-length human Beclin 1 protein.
Form Liquid
Opslagbuffer whole serum, 0.1% sodium azide
Opslagtemperatuur 4° C, do not freeze
Shipping temperature Ice

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