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Anti-HIF-PH2 Rabbit Polyclonal Antibody

Leverancier: Thermo Scientific
This antibody is expected to react with rat based on sequence homology. HIF prolyl hydroxylase 2 is a prolyl hydroxylase that modifies HIF-alpha. Classic prolyl hydroxylases are found in the endoplasmic reticulum and modify collagen, whereas HIF is an intracellular protein and the HPH sites do not resemble those modifying collagen. HIF is a transcriptional complex that plays a critical role in oxygen homeostasis. HPH is an essential component of the pathway through which cells sense oxygen. In the presence of oxygen, HPHs convert specific prolyl residues in HIF-alpha to hydroxyproline, leading to HIF-alpha destruction. Low oxygen levels, sensed at the cellular level, cause the HIF conversion to be reduced so that HIF is stable and there is increased angiogenesis. HPH-2, specifically, catalyzes the posttranslational formation of 4-hydroxyproline in HIF alpha proteins. It hydroxylates HIF-1 alpha at Pro(402) and Pro(564), and HIF-2 alpha. It targets HIF through the hydroxylation for proteasomal degradation via the von Hippel-Lindau ubiquitylation complex.

Type: Primary
Antigen: HIF-PH2
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse



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Maat VPE VWR catalogus nummer Hoeveelheid
100 µL 100 µl PIEAPA116946 Blocked
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Specificaties

Antigen symbol HIF-PH2
Antigen name HIF Prolyl Hydroxylase 2
Reactivity Mouse, Human
Conjugation Unconjugated
Clonality Polyclonal
Antibody type Primary
Host Rabbit
Isotype IgG
Western Blot Yes
ImmunoChemistry Yes
ImmunoPrecipitation Yes
ImmunoFluorescence Yes
Antigen synonyms Chromosome 1 Open Reading Frame 12 antibody, EGL 9 homolog of C. elegans 1 antibody, C1ORF12 antibody, HIF Prolyl Hydroxylase 2, EGLN 1 EGLN1 antibody
Gene ID 54583, 112405
Concentratie 1 mg/ml
Immunogen Synthetic peptide between amino acids 300-400 of the mouse HPH-2 protein.
Purification Antigen affinity chromatography
Form Liquid
Opslagbuffer PBS, 0.02% sodium azide
Opslagtemperatuur 4° C, do not freeze
Shipping Temperature Ice
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