About this item
Recognizes a protein of 33-55 kDa, identified as CD53 (Workshop V; Code CD53.1). CD53 is expressed on monocytes, and macrophages, granulocytes, dendritic cells, osteoblasts and osteoclasts, NK cells, and on T- and B-cells from every stage of differentiation but is absent from platelets, erythrocytes, and non-haemopoietic cells. CD53 is a member of a family of tetraspan transmembrane proteins, including CD9, CD37, CD63, CD81, and CD82. It associates with integrins, MHC class II molecules, and a tyrosine phosphatase and plays a role in cellular activation as part of a signal transduction complex involving other membrane glycoproteins. Defects of CD53 expression on neutrophils appear to be related with recurrent infectious diseases. Cross-linking CD53 using CD53 antibodies led to cytoplasmic calcium fluxes in B cells, monocytes, and granulocytes and activation of the monocyte oxidative burst.
Type: Primary
Antigen: CD53
Clonality: Monoclonal
Clone: 63-5A3
Conjugation: Biotin
Epitope:
Host: Mouse
Isotype: IgG2b kappa
Reactivity: Human
Specifications
- Catalog No:
- BNCB0356-500
- BNCB0356-100
- Antigen symbol:
- CD53
- CD53
- Antigen synonyms:
- Leukocyte surface antigen CD53|CD53 glycoprotein|CD53 tetraspan antigen|TSPAN25|Tetraspanin-25 (Tspan-25)|Cell surface glycoprotein CD53
- Leukocyte surface antigen CD53|CD53 glycoprotein|CD53 tetraspan antigen|TSPAN25|Tetraspanin-25 (Tspan-25)|Cell surface glycoprotein CD53
- Antibody type:
- Primary
- Primary
- Clonality:
- Monoclonal
- Monoclonal
- Conjugation:
- Biotin
- Biotin
- Clone:
- Clone 63-5A3
- Clone 63-5A3
- Reactivity:
- Human
- Human
- Host:
- Mouse
- Mouse
- Gene ID:
- 443057
- 443057
- Isotype:
- IgG2b kappa
- IgG2b kappa
- ImmunoFluorescence:
- Yes
- Yes
- Concentration:
- 0,1 mg/ml
- 0,1 mg/ml
- Storage buffer:
- PBS/0,1% BSA/0,05% azide
- PBS/0,1% BSA/0,05% azide
Specifications
Product Information
- Catalog #Supplier #SizePkAvailabilityPrice
- Specifications:
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Specifications
Antigen symbolCD53Environmentally PreferableAntigen synonymsLeukocyte surface antigen CD53|CD53 glycoprotein|CD53 tetraspan antigen|TSPAN25|Tetraspanin-25 (Tspan-25)|Cell surface glycoprotein CD53Antibody typePrimaryClonalityMonoclonalConjugationBiotinCloneClone 63-5A3ReactivityHumanHostMouseGene ID443057IsotypeIgG2b kappaImmunoFluorescenceYesConcentration0,1 mg/mlStorage bufferPBS/0,1% BSA/0,05% azide - Specifications:
More
Specifications
Antigen symbolCD53Environmentally PreferableAntigen synonymsLeukocyte surface antigen CD53|CD53 glycoprotein|CD53 tetraspan antigen|TSPAN25|Tetraspanin-25 (Tspan-25)|Cell surface glycoprotein CD53Antibody typePrimaryClonalityMonoclonalConjugationBiotinCloneClone 63-5A3ReactivityHumanHostMouseGene ID443057IsotypeIgG2b kappaImmunoFluorescenceYesConcentration0,1 mg/mlStorage bufferPBS/0,1% BSA/0,05% azide