Recognizes a protein of ~55 kDa, identified as SOX10. This MAb is highly specific and does not cross-react with other members of the SOX-family. SOX genes comprise a family of genes that are related to the mammalian sex-determining gene SRY. These genes similarly contain sequences that encode for the HMG-box domain, which is responsible for the sequence-specific DNA-binding activity. SOX-10 is a sensitive marker of melanoma, including conventional, spindled, and desmoplastic subtypes. It is expressed by metastatic melanomas and nodal capsular nevus in sentinel lymph nodes, but not by other lymph node components such as dendritic cells, which usually express S100 protein. Commonly used melanoma markers, such as anti-HMB-45 and anti-Melan-A, are poorly expressed in desmoplastic melanomas while SOX-10 is moderately to strongly expressed in desmoplastic melanomas. SOX-10 is considered as a very reliable marker for recognizing residual desmoplastic melanomas. In normal tissues, it is expressed in Schwann cells, melanocytes, and myoepithelial cells of salivary, bronchial and mammary glands. SOX-10 expression is also observed in mast cells.
- Purified
Type: Primary
Antigen: SOX10
Clonality: Monoclonal
Clone: SOX10/991 SOX10/1074
Conjugation: Purified
Epitope:
Host: Mouse
Isotype: IgG2b kappa
Reactivity: Human
- Catalog No:
- BNUB1074-100
- BNUB1074-500
- Antigen symbol:
- SOX10
- SOX10
- Antigen synonyms:
- Waardenburg syndrome type 2E (WS2E)|PCWH|WS4|SRY (sex determining region Y) box 10|Waardenburg syndrome type 4C (WS4C)|DOM|SRY box containing gene 10|SOX10|SRY related HMG box gene 10
- Waardenburg syndrome type 2E (WS2E)|PCWH|WS4|SRY (sex determining region Y) box 10|Waardenburg syndrome type 4C (WS4C)|DOM|SRY box containing gene 10|SOX10|SRY related HMG box gene 10
- Antibody type:
- Primary
- Primary
- Clonality:
- Monoclonal
- Monoclonal
- Conjugation:
- Unconjugated
- Unconjugated
- Clone:
- Clone SOX10/991 SOX10/1074
- Clone SOX10/991 SOX10/1074
- Reactivity:
- Human
- Human
- Host:
- Mouse
- Mouse
- Gene ID:
- 181244; 654404; 77961
- 181244; 654404; 77961
- Isotype:
- IgG2b kappa
- IgG2b kappa
- Western blot:
- Yes
- Yes
- ImmunoChemistry:
- Yes
- Yes
- ImmunoFluorescence:
- Yes
- Yes
- Concentration:
- 0,2 mg/ml
- 0,2 mg/ml
- Storage buffer:
- PBS/0,05% BSA/0,05% azide
- PBS/0,05% BSA/0,05% azide
Product Information
- SizePk
Specifications
Antigen symbolSOX10Environmentally PreferableAntigen synonymsWaardenburg syndrome type 2E (WS2E)|PCWH|WS4|SRY (sex determining region Y) box 10|Waardenburg syndrome type 4C (WS4C)|DOM|SRY box containing gene 10|SOX10|SRY related HMG box gene 10Antibody typePrimaryClonalityMonoclonalConjugationUnconjugatedCloneClone SOX10/991 SOX10/1074ReactivityHumanHostMouseGene ID181244; 654404; 77961IsotypeIgG2b kappaWestern blotYesImmunoChemistryYesImmunoFluorescenceYesConcentration0,2 mg/mlStorage bufferPBS/0,05% BSA/0,05% azideSpecifications
Antigen symbolSOX10Environmentally PreferableAntigen synonymsWaardenburg syndrome type 2E (WS2E)|PCWH|WS4|SRY (sex determining region Y) box 10|Waardenburg syndrome type 4C (WS4C)|DOM|SRY box containing gene 10|SOX10|SRY related HMG box gene 10Antibody typePrimaryClonalityMonoclonalConjugationUnconjugatedCloneClone SOX10/991 SOX10/1074ReactivityHumanHostMouseGene ID181244; 654404; 77961IsotypeIgG2b kappaWestern blotYesImmunoChemistryYesImmunoFluorescenceYesConcentration0,2 mg/mlStorage bufferPBS/0,05% BSA/0,05% azide