Recognizes a protein of ~55 kDa, identified as SOX10. This MAb is highly specific and does not cross-react with other members of the SOX-family. SOX genes comprise a family of genes that are related to the mammalian sex-determining gene SRY. These genes similarly contain sequences that encode for the HMG-box domain, which is responsible for the sequence-specific DNA-binding activity. SOX-10 is a sensitive marker of melanoma, including conventional, spindled, and desmoplastic subtypes. It is expressed by metastatic melanomas and nodal capsular nevus in sentinel lymph nodes, but not by other lymph node components such as dendritic cells, which usually express S100 protein. Commonly used melanoma markers, such as anti-HMB-45 and anti-Melan-A, are poorly expressed in desmoplastic melanomas while SOX-10 is moderately to strongly expressed in desmoplastic melanomas. SOX-10 is considered as a very reliable marker for recognizing residual desmoplastic melanomas. In normal tissues, it is expressed in Schwann cells, melanocytes, and myoepithelial cells of salivary, bronchial and mammary glands. SOX-10 expression is also observed in mast cells.
Type: Primary
Antigen: SOX10
Clonality: Monoclonal
Clone: SOX10/991 SOX10/1074
Conjugation: CF594
Epitope:
Host: Mouse
Isotype: IgG2b kappa
Reactivity: Human
- Catalog No:
- BNC941074-100
- BNC941074-500
- antigeen symbool:
- SOX10
- SOX10
- Antigeen synoniemen:
- Waardenburg syndrome type 2E (WS2E)|PCWH|WS4|SRY (sex determining region Y) box 10|Waardenburg syndrome type 4C (WS4C)|DOM|SRY box containing gene 10|SOX10|SRY related HMG box gene 10
- Waardenburg syndrome type 2E (WS2E)|PCWH|WS4|SRY (sex determining region Y) box 10|Waardenburg syndrome type 4C (WS4C)|DOM|SRY box containing gene 10|SOX10|SRY related HMG box gene 10
- Type antilichaam:
- Primair
- Primair
- Clonality:
- Monoklonaal
- Monoklonaal
- Conjugatie:
- CF® 594
- CF® 594
- Clone:
- Clone SOX10/991 SOX10/1074
- Clone SOX10/991 SOX10/1074
- Reactivity:
- Human
- Human
- Host:
- Mouse
- Mouse
- Gen-ID:
- 376984
- 376984
- Isotype:
- IgG2b kappa
- IgG2b kappa
- Western blot:
- Yes
- Yes
- ImmunoChemie:
- Yes
- Yes
- ImmunoFluorescentie:
- Yes
- Yes
- Concentratie:
- 0,1 mg/ml
- 0,1 mg/ml
- Opslagbuffer:
- PBS/0,1% BSA/0,05% azide
- PBS/0,1% BSA/0,05% azide
Product Information
- Catalog #Supplier #MaatVPEAvailabilityPrice
- BNC941074-100BNC941074-100100 μL100 µl1 * 100 µl203,00 €
Specifications
antigeen symboolSOX10Environmentally PreferableAntigeen synoniemenWaardenburg syndrome type 2E (WS2E)|PCWH|WS4|SRY (sex determining region Y) box 10|Waardenburg syndrome type 4C (WS4C)|DOM|SRY box containing gene 10|SOX10|SRY related HMG box gene 10Type antilichaamPrimairClonalityMonoklonaalConjugatieCF® 594CloneClone SOX10/991 SOX10/1074ReactivityHumanHostMouseGen-ID376984IsotypeIgG2b kappaWestern blotYesImmunoChemieYesImmunoFluorescentieYesConcentratie0,1 mg/mlOpslagbufferPBS/0,1% BSA/0,05% azide Specifications
antigeen symboolSOX10Environmentally PreferableAntigeen synoniemenWaardenburg syndrome type 2E (WS2E)|PCWH|WS4|SRY (sex determining region Y) box 10|Waardenburg syndrome type 4C (WS4C)|DOM|SRY box containing gene 10|SOX10|SRY related HMG box gene 10Type antilichaamPrimairClonalityMonoklonaalConjugatieCF® 594CloneClone SOX10/991 SOX10/1074ReactivityHumanHostMouseGen-ID376984IsotypeIgG2b kappaWestern blotYesImmunoChemieYesImmunoFluorescentieYesConcentratie0,1 mg/mlOpslagbufferPBS/0,1% BSA/0,05% azide