Leukemia detection kit, LEUCOGNOST® NASDCL

Leverancier: Merck
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LEUCOGNOST®
MERC1.17198.0001EA 380 EUR
MERC1.17198.0001
Leukemia detection kit, LEUCOGNOST® NASDCL
LEUCOGNOST NASDCL enables the semi-quantitative localization of naphthol AS-D chloroacetate esterase activity in leukocytes via the enzymatic hydrolysis of naphthol AS-D chloroacetate to a naphthol compound.

This product, in turn, reacts with a diazonium salt to form an insoluble red-violet dye.

It features an improved formulation, which produces a subtle coloration of cytoplasmic granules within granulopoietic cells, thus making detection of acute myeloblastic leukemia (AML) easier. This version has been developed and characterised to achieve a high degree of standardization using both native blood and bone marrow smears.

LEUCOGNOST NASDCL reacts clearly with both mature and immature granulocytes. Intense enzyme activity can also be detected in myelocytes, metamyelocytes, stab cells and mast cells. Activity may also be detected in myeloblastic leukemia cells, promyelocytes and Auer bodies. Monocytes are rarely reactive. Eosinophils, basophils, megakaryocytes, lymphocytes, plasma cells and red cell precursors show no or at most very weak reaction.

Certificaten: Developed and registered as CE/IVD product for applications in diagnostics.

Leveringsinformatie: Sufficient for 12 stainings with up to 16 slides. Includes Tris buffer concentrate, 2x 62 ml ; Naphthol AS-D chloroacetate, 12x 20 mg ; Dimethylformamide (DMF), 13 ml ; Pararosaniline solution, 12x 1 ml ; Sodium nitrite solution, 7 ml.
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