About this item
Granulocyte-colony stimulating factor (G-CSF) is a cytokine that functions as a potent inducer of neutrophilic granulocyte proliferation, terminal differentiation, and activation. G-CSF synthesis occurs in monocyte, macrophage, epithelial, endothelial, and fibroblast cells after activation by bacterial endotoxins, tumor necrosis factor alpha (TNF-α), interleukin 1 (IL-1), or interleukin 17 (IL-17). The functional activity of G-CSF is mediated through the granulocyte colony-stimulating factor receptor (G-CSF-R) to activate JAK/STAT and MAPK signal transduction pathways. G-CSF also promotes neurogenesis and inhibits neuronal apoptosis. Human and mouse G-CSF proteins are cross-reactive.
- High Quality
- Low Endotoxin
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A COA is supplied with each product shipped detailing purity, formulation, biological activity, endotoxin levels, reconstitution instructions and recommended storage conditions. This product is for research use only and is not for use in humans.
Specifications
- Conjugation:Unconjugated
- Protein function:Cytokine
- Protein/peptide type:Recombinant
- Source:E. coli
- Species:Mouse
- Storage conditions:–20 °C
- Endotoxin content:Endotoxin LAL (EU/µg) ≤0,1
- Biological activity:Bioactivity assay: NFS-60 cell proliferation, ED50 ≤0,05 ng/ml, Bioactivity ≥2,0×10⁷ units/mg
- Gene ID:P09920
- Reconstitution instructions:Sterile water at 0.1 mg/ml
- Endotoxin-free:N
- Carrier-free:Y
- Protease-free:N
- Animal-free:N
- Protein synonyms:GM-CSFβ|pluripoietin|MGI-1G|CSF-3
- Protein/peptide name:G-CSF
- Purity:≥95%
- Molecular weight:19,1 kDa
- Sequence:MVPLVTVSAL PPSLPLPRSF LLKSLEQVRK IQASGSVLLE QLCATYKLCH PEELVLLGHS LGIPKASLSG CSSQALQQTQ CLSQLHSGLC LYQGLLQALS GISPALAPTL DLLQLDVANF ATTIWQQMEN LGVAPTVQPT QSAMPAFTSA FQRRAGGVLA ISYLQGFLET ARLALHHLA
- Endotoxin level:Low
- Formulation:10 mM sodium citrate, pH 3,0
- Nuclease-free:N
- Grade:RUO
- Shipping temperature:RT
- Tested applications:Bioassay
Specifications
Product Information
- Catalog #Supplier #Pack typePkAvailabilityPrice
- Supplier Article Number: 200-14-10UGLocal Article Number: SHBT200-14-10UG
- Supplier Article Number: 200-14-100UGLocal Article Number: SHBT200-14-100UG
- Supplier Article Number: 200-14-500UGLocal Article Number: SHBT200-14-500UG
- Supplier Article Number: 200-14-1MGLocal Article Number: SHBT200-14-1MG